电脑版

杨巍

时间:2019-12-17浏览:79

基本信息:

姓名: 杨巍
职务: 基础医学院副院长
职称: 教授
学历: 博士
专业: 神经生物学
所属院系: 基础医学系
研究方向: 主要从事离子通道的结构与功能关系、细胞信号传导及对离子通道的调节机制研究。
电话:
信箱: yangwei@zju.edu.cn
个人主页: https://person.zju.edu.cn/yangwei0219#0

个人概况:

基本信息

1997年本科毕业于杭州大学生命科学学院(于1998年合并入www.402.com)。1997年8月-1999年6月在杭州大学校团委工作,任社会实践部部长。2001年进入永利402com官方网站生理学专业攻读硕士学位。2004年9月-2005年1月在中科院上海分院神经科学研究所段树民院士实验室进行合作课题研究。2005年进入永利402com官方网站神经生物学专业攻读博士,从事NMDA受体C末端对NMDA受体装配和膜运输的调节机制研究。2006年7月-10月在英国利兹大学膜系统生物学研究所进行合作课题研究并进修电生理膜片钳技术,期间参与研究了TRPM2离子通道的通透性功能研究。2008年6月博士毕业至今,在www.402.com神经科学研究所工作。2009年6月,获得英国皇家学会SBFT-Royal Society Incoming Fellowship资助,赴英国利兹大学进行为期两年的访问研究。2011年被遴选为www.402.com求是青年学者,2012年1月晋升为副教授。2014年1-7月获得国家留学基金委资助,赴美国加州戴维斯分校物理与膜生物学系访问研究。2016年1月晋升为教授。2017年任命为www.402.com基础医学院副院长。

 主要从事离子通道的结构与功能关系、细胞信号传导及对离子通道的调节机制研究。已在Cell Research,Nature Chemical Biology,JBC,Cell Death Disease,Scientific Reports, British Journal Pharma,PLoS One等国际著名期刊发表SCI论文数十篇,被Nat Rev Neurosci, Pharmacol Rev, J Neurosci, J Biol Chem等国际著名期刊引用100余次。为Scientific Reports, Molecular Neurobiology, PLoS ONE, Neuroscience Bulletin, Acta Pharma Sin等杂志审稿人。目前负责主持:国家科技部蛋白质重大研究计划(973)子课题一项,国家自然科学基金面上项目两项,浙江省自然科学杰出青年基金一项,浙江省钱江人才计划一项;负责完成国家自然科学基金一项,海外合作项目一项,省自然科学基金和省教育厅基金各一项;并参与国家自然基金重点项目以及973项目两项。近年来多次受邀在国内外学术会议上做学术报告,曾获得2015年度中国生理学会张锡钧基金优秀青年论文一等奖(唯一),2007年度中国神经学会青年学术论坛一等奖(唯一),2011年海内外华人离子通道大会最佳墙报奖等荣誉。


在研项目

1.  国家自然科学面上基金,短暂性脑缺血复灌后TRPM2介导自噬抑制引发神经元死亡的作用机制,2016-2019;68.4万元,主持人(在研)

2.  浙江省自然科学杰出青年基金,TRPM2调控自噬功能及其在短暂性脑缺血/复灌引发神经元死亡中的作用机制研究,2016-2019;40万元,主持人(在研)

3.  国家自然科学面上基金,TRPM2在全脑缺血/再灌注损伤引发海马CA1区神经元迟发性死亡中的作用,2014-2017;70万元,主持人(已结题)

4.  科技部蛋白质重大研究计划,活细胞中探测蛋白质动态学的新技术新方法, 2013-2017;633万元,主持人(已结题)

5.  浙江省钱江人才计划,TRPM2在帕金森氏症病理发生的作用及其机制,2012-2013;10万元,主持人(已结题)

6.  国家自然科学基金青年项目,酪氨酸磷酸酶Shp2对海马的突触功能学习记忆的作用,2010-2012;19万,主持(已结题)

7.  Sino-British Fellow Trust-Royal Society Incoming Fellowship (Belong to Newton International Fellowship Scheme,英国牛顿国际奖学金),2009-2011,66000 GBP(折合人民币约70万),主持(已结题)

8.  浙江省自然基金面上项目,射频电磁波对培养神经元的突触可塑性以及树突发育的作用,2005.01-2008.12,5.5万,主持(已结题)


发表论文:

  1. Wang J#, Lv X#, Wu Y, Xu T, Jiao M, Yang R, Li X, Chen M, Yan Y, Chen C, Dong W, Yang W, Zhuo M, Chen T*, Luo J*, Qiu S*. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons[J]. Nature communications, 2018, 9(1): 2267.

  2.       Luo Y, Yu X, Ma C, Luo J, Yang W*. Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity. Frontiers in pharmacology, 2018, 9.

  3. Zhang H, Liu H, Luo X, Wang Y, Liu Y, Jin H, Liu Z, Yang W, Yu P*, Zhang L*, Zhang L.Design, synthesis and biological activities of 2, 3-dihydroquinazolin-4 (1H)-one derivatives as TRPM2 inhibitors[J]. European journal of medicinal chemistry, 2018.

  4. Luo X, Li M, Zhan K, Yang W, Zhang L, Wang K*, Yu P*, Zhang L*. Selective inhibition of TRPM 2 channel by two novel synthesized ADPR analogues[J]. Chemical biology & drug design, 2018, 91(2): 552-566.

  5. Li X, Yang W, Jiang L H*. Alteration in intracellular Zn2+ homeostasis as a result of TRPM2 channel activation contributes to ROS-induced hippocampal neuronal death[J]. Frontiers in molecular neuroscience, 2017, 10: 414.

  6.       Jiang Q, Gao Y, Wang C, Tao RR, Wu Y, Zhan K, Liao MH, Lu N, Lu YM, Wilcox CS, Luo J, Jiang LH*, Yang W*, Han F*. Nitration of TRPM2 as a Molecular Switch Induces Autophagy during Brain Pericyte Injury[J]. Antioxidants & Redox Signaling, 2017.

  7.       Yu P, Xue X, Zhang J, Hu X, Wu Y, Jiang LH, Jin H, Luo J, Zhang L, Liu Z*, Yang W*. Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2[J]. The Journal of general physiology, 2017, 149(2): 219-235.

  8.      Yan X, Zhang B, Lu W, Peng L, Yang Q, Cao W, Lin S, Yu W, Li X, Ke Y, Li S, Yang W*, Luo J*. Increased Src Family Kinase Activity Disrupts Excitatory Synaptic Transmission and Impairs Remote Fear Memory in Forebrain Shp2-Deficient Mice[J]. Molecular neurobiology, 2016: 1-16.

  9.      Zhan K, Yu P, Liu C, Luo J, Yang W*. Detrimental or beneficial: the role of TRPM2 in ischemia/reperfusion injury[J]. Acta Pharmacologica Sinica, 2016,37(1): 4-12.

  10.       Yu P, Li J, Jiang J, Zhao Z, Hui Z, Zhang J, Zheng Y, Ling D, Wang L, Jiang LH, Luo J, Zhu X*, Yang W*. A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles[J]. Scientific reports, 2015, 5: 18171.

  11.       Tang Y, Ye M, Du Y, Qiu X, Lv X, Yang W, Luo J. EGFR signaling upregulates surface expression of the GluN2B-containing NMDA receptor and contributes to long-term potentiation in the hippocampus[J]. Neuroscience, 2015, 304: 109-121.

  12.       Yang F, Xiao X, Cheng W, Yang W, Yu P, Song Z, Yarov-Yarovoy V, Zheng J. Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel[J]. Nature chemical biology, 2015, 11(7): 518-524.

  13.       Xiaomin Zhang, Xunyi Yan, Bin Zhang, Qian Yang, Mao Ye, Wei Cao, Wenbin Qiang, Lijun Zhu, Yonglan Du, Xingxing Xu, Jiasheng Wang, Fei Xu, Wen Lu, Shuang Qiu*, Wei Yang*, Jianhong Luo*. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory[J]. Cell research, 2015, 25(7): 818-836.

  14.      Wen Lu, Weiqing Fang, Jian Li, Bin Zhang, Qian Yang, Xunyi Yan, Lin Peng,Heng Ai, Jie-jie Wang, Xiao Liu, Jianhong Luo*, Wei Yang*. Phosphorylation of tyrosine Y1070 at the GluN2B subunit is regulated by synaptic activity and critical for surface expression of N-methyl-D-aspartate (NMDA) receptors[J]. Journal of Biological Chemistry, 2015, 290(38): 22945-22954.

  15.       Chen P, Wu JZ, Zhao J, Wang P, Luo J, Yang W*, Liu XD. PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium-dependent inactivation[J]. European Biophysics Journal, 2015, 44(6): 483-492.

  16.       Manna PT, Munsey TS, Abuarab N, Li F, Asipu A, Howell G, Sedo A, Yang W, Naylor J, Beech DJ, Jiang LH, Sivaprasadarao A. TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death[J]. Biochemical Journal, 2015, 466(3): 537-546.

  17.       Mao Ye#Wei Yang#*, Justi F Ainscough, Xupang Hu, Xin Li, Alicia Sedo, Xinheng Zhang, Xiangnan Zhang, Zhong Chen, Xiaoming Li, David J Beech, Asipu Sivaprasadarao, Jianhong Luo*, Lin-Hua Jiang*. TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia[J]. Cell death & disease, 2014, 5(11): e1541.

  18.       Wenyue Yu, Lin-Hua Jiang, Yang Zheng, Xupang Hu, Jianhong Luo* and Wei Yang*. Inactivation of TRPM2 channels by extracellular divalent copper[J]. PloS one, 2014, 9(11): e112071.

  19.        Heng Ai, Wen Lu, Mao Ye, Wei Yang*Synaptic non-GluN2B-containing NMDA receptors regulate tyrosine phosphorylation of GluN2B 1472 tyrosine site in rat brain slices[J]. Neuroscience bulletin, 2013, 29(5): 614-620.

  20.       Zou J, Ainscough JF, Yang W, Sedo A, Yu SP, Mei ZZ, Sivaprasadarao A, Beech DJ, Jiang LH. A differential role of macrophage TRPM2 channels in Ca2+ signaling and cell death in early responses to H2O2[J]. American Journal of Physiology-Cell Physiology, 2013, 305(1): C61-C69.

  21. Yang W, Jiang L H. Site-directed mutagenesis to study the structure–function relationships of ion channels[M]//Ion Channels. Humana Press, Totowa, NJ, 2013: 257-266.

  22. Zhu J, Shao CY, Yang W, Zhang XM, Wu ZY, Zhou L, Wang XX, Li YH, Xia J, Luo JH, Shen Y. Chronic zinc exposure decreases the surface expression of NR2A-containing NMDA receptors in cultured hippocampal neurons[J]. PloS one, 2012, 7(9): e46012.

  23.       Ai H#, Yang W#, Ye M, Lu W, Yao L, Luo JH. Differential regulation of AMPA receptor GluA1 phosphorylation at serine 831 and 845 associated with activation of NMDA receptor subpopulations[J]. Neuroscience letters, 2011, 497(2): 94-98.

  24.        Bradley HJ, Browne LE, Yang W, Jiang LH. Pharmacological properties of the rhesus macaque monkey P2X7 receptor[J].British journal of pharmacology, 2011, 164(2b): 743-754.

  25.       Zou J, Yang W, Beech DJ, Jiang LH. A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH[J]. Pflügers Archiv-European Journal of Physiology, 2011, 462(2): 293-302.

  26.       Yang W, Manna PT, Zou J, Luo J, Beech DJ, Sivaprasadarao A, Jiang LH. Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore[J]. Journal of Biological Chemistry, 2011, 286(27): 23789-23798.

  27.      Jiang LH*, Yang W, Zou J, Beech DJ. TRPM2 channel properties, functions and therapeutic potentials[J]. Expert opinion on therapeutic targets, 2010, 14(9): 973-988.

  28.       Yang W, Zou J, Xia R, Vaal ML, Seymour VA, Luo J, Beech DJ, Jiang LH. State-dependent inhibition of TRPM2 channel by acidic 

           pH[J]. Journal of Biological Chemistry, 2010, 285(40): 30411-30418.

  29. Chen P, Liu XD, Zhang W, Zhou J, Wang P, Yang W, Luo J. Modeling and simulation of ion channels and action potentials in taste receptor cells[J]. Science in China Series C: Life Sciences, 2009, 52(11): 1036-1047.

  30. Qiu S, Zhang XM, Cao JY, Yang W, Yan YG, Shan L, Zheng J, Luo JH. An endoplasmic reticulum retention signal located in the extracellular amino-terminal domain of the NR2A subunit of N-Methyl-D-aspartate receptors[J]. Journal of Biological Chemistry, 2009, 284(30): 20285-20298.

  31. Xia R, Mei ZZ, Mao HJ, Yang W, Dong L, Bradley H, Beech DJ, Jiang LH. Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2[J]. Journal of Biological Chemistry, 2008, 283(41): 27426-27432.

发明专利:

1.   余沛霖,宋珍甄,罗建红,杨巍一种特异性标记的辣椒素荧光探针及其合成方法和应用。已授权。

参编著作:

1.  Gamper, Nikita et al. Ion Channels Methods and Protocols (英文著作),美国,Humana Press,2013年1月,2.4/65万字。

2.  罗建红 等,医学分子细胞生物学研究策略与技术原理,著作,北京,科学出版社,2012年2月,2.1/48万字。

XML 地图 | Sitemap 地图